{"id":10099,"date":"2025-03-01T14:02:43","date_gmt":"2025-03-01T19:02:43","guid":{"rendered":"https:\/\/dhss.delaware.gov\/dph\/dhan143\/"},"modified":"2025-03-02T00:47:21","modified_gmt":"2025-03-02T05:47:21","slug":"dhan143","status":"publish","type":"page","link":"https:\/\/dhss.delaware.gov\/dph\/php\/alerts\/dhan143\/","title":{"rendered":"php\/alerts\/dhan143 ~  Division of Public Health &#8211; &#8211; Health Alert  &#8211; Delaware Health and Social Services &#8211; State of Delaware"},"content":{"rendered":"<div data-swiftype-index=\"true\">\n\n\n\n  <br>\n\n\n\n  <div class=\"container\" id=\"main_header\"> \n\n    <!-- BEGIN readspeaker div -->\n\n    <div class=\"rs_skip rsbtn rs_preserve\" id=\"readspeaker_button1\">\n\n      <a accesskey=\"L\" class=\"rsbtn_play\" href=\"https:\/\/app-na.readspeaker.com\/cgi-bin\/rsent?customerid=7262&#038;lang=en_us&#038;readid=main_content&#038;url=https:\/\/dhss.delaware.gov\/dph\/php\/alerts\/dhan143.html\" title=\"Listen to this page using ReadSpeaker\">\n\n        <span class=\"rsbtn_left rsimg rspart\"><span class=\"rsbtn_text\"><span>Listen<\/span><\/span><\/span>\n\n        <span class=\"rsbtn_right rsimg rsplay rspart\"><\/span>\n\n      <\/a>\n\n    <\/div>\n\n    <!-- END readspeaker div -->\n\n\n\n    \n\n    <header class=\"pull-left\">\n\n      <h1>Delaware Health Alert Network #<!--[type=EDIT name=\"DHAN Number\"]-->143 <!--[END]--> <\/h1>\n\n      <h2> <!--[type=EDIT name=\"DHAN Date\"]-->December 13, 2007 10:57am <!--[END]--> <\/h2>\n\n    <\/header>\n\n  <\/div><br>\n\n \n\n  <div class=\"container\">\n\n    <div class=\"row\">\n\n      <div class=\"col-md-3\" id=\"leftCol\">\n\n        <div class=\"panel-group\" id=\"accordion\">\n\n          <div class=\"panel sectionmenu_panel\">\n\n            <div class=\"panel-heading\">\n\n              <p class=\"panel-title\"><a class=\"agency_nav\" data-parent=\"#accordion\" data-toggle=\"collapse\" href=\"#collapseOne\"><strong><i class=\"fa fa-align-justify fa-fw\"><\/i> Public Health Menu<\/strong><\/a><\/p>\n\n            <\/div>\n\n\n\n            <div class=\"panel-collapse collapse in\" id=\"collapseOne\">\n\n              <div class=\"panel-body\" id=\"clf_nav\">\n\n                  <ul class=\"nav nav-stacked nav-pills-clf\" id=\"agency_sidebar\">\n    <li><a href=\"\/dph\/\"><h2>Home <i class=\"fa fa-home fa-fw\"><\/i><\/h2><\/a><\/li>\n    <li class=\"toplevel\"><a data-parent=\"#agency_sidebar\" data-toggle=\"collapse\" href=\"#HomeMenu\"><h2>About <i class=\"fa fa-caret-right fa-fw\"><\/i><\/h2><\/a>\n      <ul class=\"panel-collapse collapse\" id=\"HomeMenu\">\n        <li><a href=\"\/dph\/about.html\">About DPH<\/a><\/li>\n        <li><a href=\"\/dph\/sections.html\">Sections &#038; 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Co. will announce that it has initiated a voluntary recall in the United States for certain lots of\n\n\n  PedvaxHIB\u00ae [Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate)] and COMVAX\u00ae [Haemophilus b Conjugate\n\n\n  (Meningococcal Protein Conjugate) and Hepatitis B (Recombinant) Vaccine].\n\n\n<\/p>\n\n\n<p>\n\n\n  CDC understands that this recall will present several challenges to our public health and provider partners. We are working rapidly to\n\n\n  gather and assess information which will allow us to develop guidance for immunization providers and their patients. We will continue to\n\n\n  release information as it becomes available.\n\n\n<\/p>\n\n\n<ol>\n\n\n  <li>\n\n\n    <strong>What vaccine is being recalled?<\/strong><br>\n\n\n    Merck &#038; Co. has initiated a voluntary recall in the United States for ten lots of PedvaxHIB\u00ae [Haemophilus b Conjugate Vaccine\n\n\n    (Meningococcal Protein Conjugate)] and two lots of COMVAX\u00ae [Haemophilus b Conjugate (Meningococcal Protein Conjugate) and Hepatitis\n\n\n    B (Recombinant) Vaccine]. The affected doses were distributed in the U.S. starting in April 2007.<br>\n\n\n    <br>\n\n\n    The lots that are being recalled are:<br>\n\n\n    <br>\n\n\n    <table class=\"table table-condensed table-hover\">\n\n\n      <tbody><tr>\n\n\n        <th scope=\"col\">\n\n\n          PRODUCT DESCRIPTION\n\n\n        <\/th>\n\n\n        <th scope=\"col\">\n\n\n          LOT #\n\n\n        <\/th>\n\n\n        <th scope=\"col\">\n\n\n          EXP. DATE\n\n\n        <\/th>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0677U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          11 January 2010\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0820U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          12 January 2010\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0995U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          16 January 2010\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          1164U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          18 January 2010\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0259U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          17 October 2009\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0435U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          18 October 2009\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0436U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          19 October 2009\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0437U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          19 October 2009\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0819U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          09 January 2010\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          PedvaxHIB\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          1167U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          10 January 2010\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          COMVAX\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0376U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          05 January 2010\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n      <tr>\n\n\n        <td class=\"text-center\">\n\n\n          COMVAX\u00ae\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          0377U\n\n\n        <\/td>\n\n\n        <td class=\"text-center\">\n\n\n          08 January 2010\n\n\n        <\/td>\n\n\n      <\/tr>\n\n\n    <\/tbody><\/table><br>\n\n\n    No other lots of PedvaxHIB\u00ae or COMVAX\u00ae and no other Merck products are affected by this recall.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>Why are these lots being recalled?<br><\/strong> Merck is taking this step as a precautionary measure. The company cannot assure\n\n\n    sterility for these specific vaccine lots. The potential contamination in these specific lots was identified as part of Merck\u2019s\n\n\n    standard evaluation of their manufacturing processes. In routine testing of the vaccine manufacturing equipment used to produce\n\n\n    PedvaxHIB\u00ae and COMVAX\u00ae, Merck identified the presence of a certain bacteria called Bacillus cereus. Sterility tests of the\n\n\n    vaccine lots themselves have not found any contamination.<br>\n\n\n    <br>\n\n\n    The potential for contamination of any individual vaccine is low, and, if present, the level of contamination would be low. However,\n\n\n    because they cannot guarantee the sterility of these specific lots of vaccine, Merck is conducting this recall.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>What is the extent of the recall?<\/strong><br>\n\n\n    About 1 million doses of vaccine are being recalled, including ten lots of PedvaxHIB\u00ae and two lots of COMVAX\u00ae that were\n\n\n    distributed in the U.S. as well as vaccine lots within the CDC stockpile.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>Will children who received vaccine from affected lots need to be revaccinated?<br><\/strong> No. Children who received Hib\n\n\n    vaccine from affected lots do not need to be revaccinated. No potency concerns have been identified for these vaccine lots.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>What are the risks to children who received vaccine from affected lots?<br><\/strong> Sterility tests of the vaccine lots\n\n\n    themselves have not found any contamination. Merck has not received any reports of abscesses or disseminated B. cereus infection in\n\n\n    children who received vaccines from affected lots. In addition, no problems have been detected by the Vaccine Adverse Event Reporting\n\n\n    System (VAERS) related to the Hib vaccine affected by this recall. However, since sterility of the vaccine cannot be assured, if a\n\n\n    child was vaccinated with a vial of PedvaxHIB\u00ae or COMVAX\u00ae that contained B. cereus or other microorganisms, there may be a risk\n\n\n    of developing localized or disseminated infections. Immunocompromised children may be at the greater risk for these infections. These\n\n\n    infections are most likely to occur within one week after vaccination.<br>\n\n\n    <br>\n\n\n    VAERS will continue to monitor adverse events following vaccination as they are reported. Any potentially vaccine-related adverse\n\n\n    events should be reported to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967 (or at <a href=\"http:\/\/www.vaers.hhs.gov\/\">http:\/\/www.vaers.hhs.gov\/<\/a>), and to Merck at 1-800-672-6372.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>What should providers do if they have recalled lots in their office?<\/strong><br>\n\n\n    Providers should immediately discontinue use of any of the affected lots and follow Merck\u2019s instructions for returning recalled\n\n\n    vaccine (both VFC and non-VFC vaccine).\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>How does this impact the nation\u2019s Hib vaccine supply? Are there other Hib vaccine manufacturers?<\/strong><br>\n\n\n    As a result of this recall, providers who only use Merck Hib vaccines may have none, some or all of their vaccine recalled, and about\n\n\n    half of the Hib vaccine in CDC\u2019s stockpile is being recalled. CDC realizes that some providers will be faced with the prospect of\n\n\n    having children to vaccinate with no vaccine available. There are two U.S. Hib vaccine manufacturers \u2013 Merck &#038; Co., Inc. and\n\n\n    sanofi pasteur. In the past, each manufacturer has produced about half of the nation\u2019s Hib vaccine supply.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>What is CDC doing in response to the shortage of Hib vaccine?<br><\/strong>CDC is in contact with the two U.S. Hib vaccine\n\n\n    manufacturers \u2013 Merck and sanofi pasteur. CDC is assessing availability of Hib vaccine and timing of future supply, and will make\n\n\n    appropriate recommendations soon. Key considerations being addressed by CDC, along with partners such as the American Academy of\n\n\n    Pediatrics, the American Academy of Family Physicians, and a representative of CDC\u2019s Advisory Committee on Immunization\n\n\n    Practices, include whether to change recommendations for Hib vaccine temporarily and how to allocate the smaller CDC stockpile of\n\n\n    Merck\u2019s Hib vaccines.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>Will the shortage of Hib vaccine result in an increase in disease occurrence of <em>Haemophilus influenza<\/em> type\n\n\n    b?<br><\/strong>Fortunately, current immunization rates in the U.S. for Hib vaccine are high. In 2006, about 94% of U.S. children 19-35\n\n\n    months of age were vaccinated against Hib. This has resulted in a dramatic decline in transmission of this bacteria; however, it has\n\n\n    not gone away completely. Experience has shown that we cannot let down our guard against vaccine-preventable diseases such as Hib. When\n\n\n    immunization rates fall we are susceptible to increases in disease occurrence, so we are taking the current situation very seriously.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>What should providers tell their patients?<br><\/strong>For the time being, providers should continue to use Hib vaccine not\n\n\n    affected by this recall according to current ACIP recommendations. If concerned parents contact their providers, they should be\n\n\n    informed that children who were vaccinated with vaccine affected by this recall do not need to be revaccinated. Although there have\n\n\n    been no reports of any adverse reactions among children who have been vaccinated, parents of children recently vaccinated with recalled\n\n\n    vaccine should watch for any signs of infection (such as redness and swelling at the injection site) and contact their providers if\n\n\n    such reactions occur. It should be emphasized that sterility tests of samples from the recalled lots have not found any contamination\n\n\n    and the potential of contamination of any individual dose of Hib vaccine is very low.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>What should providers do if they have no vaccine or little vaccine in their office?<br><\/strong>Providers with shortages of\n\n\n    vaccine may defer the booster (12-15 month-old) dose of Hib-containing vaccine in fully immunized children who are not otherwise at\n\n\n    increased risk of invasive Hib disease (see question 13). Providers who are completely out of Hib vaccine, can contact sanofi pasteur\n\n\n    regarding the availability of Hib vaccine to meet immediate short term needs.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>What should providers do if they have no or little vaccine in their office and they are a VFC provider?<br><\/strong>VFC\n\n\n    providers should contact their health department. CDC anticipates additional guidance will be available soon.\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>Are some children at high risk for Hib?<\/strong><br>\n\n\n    Yes. Children at increased risk for Hib include: children with sickle cell disease, leukemia and malignant neoplasms, HIV and certain\n\n\n    other immunocompromising conditions, asplenia, as well as American Indian and Alaska Native children. Vaccinating these children\n\n\n    according to the recommended schedule is a high priority.\n\n\n  <\/li>\n\n\n<\/ol>\n\n\n<p>\n\n\n  Please direct questions to the Division of Public Health&#8217;s Immunization Program at 1-800-282-8672.\n\n\n<\/p><!--[END]-->\n\n  \n\n        <div class=\"panel panel-danger\">\n\n          <div class=\"panel-heading\">    \n\n      <h2>Categories of Health Alert messages:<\/h2>\n\n       <\/div>\n\n       <div class=\"panel-body\">\n\n      <ul>\n\n        <li><strong>Health Alert:<\/strong> Conveys the highest level of importance; warrants immediate action or attention.<\/li>\n\n        <li><strong>Health Advisory:<\/strong> Provides important information for a specific incident or situation; may not require immediate action.<\/li>\n\n        <li><strong>Health Update:<\/strong> Provides updated information regarding an incident or situation; unlikely to require immediate action.<\/li>\n\n            <\/ul>\n\n         <div><strong>NOTE: This page is for informational purposes only and dated material (e.g. temporary websites) may not be available.<\/strong><\/div>\n\n          <\/div> \n\n        <\/div><br>  \n\n\n\n      <\/div>\n\n    <\/div>\n\n  <\/div><!-- \/container -->\n\n  <\/div>","protected":false},"excerpt":{"rendered":"<p>Listen Delaware Health Alert Network #143 December 13, 2007 10:57am Public Health Menu Home About About DPH Sections &#038; Programs Office Locations Contact Info Calendar Services A-Z Services Air &#038; Water Quality Birth, Death, &#038; Marriage Records Clinics Health Data &#038; Statistics Emergency Preparedness Health &#038; Wellness Healthy Homes Healthy Workplaces Laboratory Restaurant Inspections Screening [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":9294,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-10099","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/10099","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/comments?post=10099"}],"version-history":[{"count":1,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/10099\/revisions"}],"predecessor-version":[{"id":11275,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/10099\/revisions\/11275"}],"up":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9294"}],"wp:attachment":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/media?parent=10099"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}