{"id":10252,"date":"2025-03-01T14:03:17","date_gmt":"2025-03-01T19:03:17","guid":{"rendered":"https:\/\/dhss.delaware.gov\/dph\/dhan283\/"},"modified":"2025-03-02T00:51:20","modified_gmt":"2025-03-02T05:51:20","slug":"dhan283","status":"publish","type":"page","link":"https:\/\/dhss.delaware.gov\/dph\/php\/alerts\/dhan283\/","title":{"rendered":"php\/alerts\/dhan283 ~  Division of Public Health &#8212; Health Alert  &#8211; Delaware Health and Social Services &#8211; State of Delaware"},"content":{"rendered":"<div data-swiftype-index=\"true\">\n\n\n\n  <br>\n\n\n\n  <div class=\"container\" id=\"main_header\"> \n\n    <!-- BEGIN readspeaker div -->\n\n    <div class=\"rs_skip rsbtn rs_preserve\" id=\"readspeaker_button1\">\n\n      <a accesskey=\"L\" class=\"rsbtn_play\" href=\"https:\/\/app-na.readspeaker.com\/cgi-bin\/rsent?customerid=7262&#038;lang=en_us&#038;readid=main_content&#038;url=https:\/\/dhss.delaware.gov\/dph\/php\/alerts\/dhan283.html\" title=\"Listen to this page using ReadSpeaker\">\n\n        <span class=\"rsbtn_left rsimg rspart\"><span class=\"rsbtn_text\"><span>Listen<\/span><\/span><\/span>\n\n        <span class=\"rsbtn_right rsimg rsplay rspart\"><\/span>\n\n      <\/a>\n\n    <\/div>\n\n    <!-- END readspeaker div -->\n\n\n\n    \n\n    <header class=\"pull-left\">\n\n      <h1>Delaware Health Alert Network #<!--[type=EDIT name=\"DHAN Number\"]-->283 <!--[END]--> <\/h1>\n\n      <h2> <!--[type=EDIT name=\"DHAN Date\"]-->November 5, 2012 8:31 am <!--[END]--> <\/h2>\n\n    <\/header>\n\n  <\/div><br>\n\n \n\n  <div class=\"container\">\n\n    <div class=\"row\">\n\n      <div class=\"col-md-3\" id=\"leftCol\">\n\n        <div class=\"panel-group\" id=\"accordion\">\n\n          <div class=\"panel sectionmenu_panel\">\n\n            <div class=\"panel-heading\">\n\n              <p class=\"panel-title\"><a class=\"agency_nav\" data-parent=\"#accordion\" data-toggle=\"collapse\" href=\"#collapseOne\"><strong><i class=\"fa fa-align-justify fa-fw\"><\/i> Public Health Menu<\/strong><\/a><\/p>\n\n            <\/div>\n\n\n\n            <div class=\"panel-collapse collapse in\" id=\"collapseOne\">\n\n              <div class=\"panel-body\" id=\"clf_nav\">\n\n                  <ul class=\"nav nav-stacked nav-pills-clf\" id=\"agency_sidebar\">\n    <li><a href=\"\/dph\/\"><h2>Home <i class=\"fa fa-home fa-fw\"><\/i><\/h2><\/a><\/li>\n    <li class=\"toplevel\"><a data-parent=\"#agency_sidebar\" data-toggle=\"collapse\" href=\"#HomeMenu\"><h2>About <i class=\"fa fa-caret-right fa-fw\"><\/i><\/h2><\/a>\n      <ul class=\"panel-collapse collapse\" id=\"HomeMenu\">\n        <li><a href=\"\/dph\/about.html\">About DPH<\/a><\/li>\n        <li><a href=\"\/dph\/sections.html\">Sections &#038; 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Specifically,\n\n\n<\/p>\n\n\n<ol>\n\n\n  <li>FDA provides list of facilities that received products shipped from the New England Compounding Center (NECC). Visit below for\n\n\n  facilities\u2019 list: <a href=\"http:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/SafetyAlertsforHumanMedicalProducts\/ucm323946.htm\">\n\n\n    http:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/SafetyAlertsforHumanMedicalProducts\/ucm323946.htm<\/a>.\n\n\n  <\/li>\n\n\n  <li>CDC Issues Guidance on Management of Asymptomatic Patients Who Received Epidural or Paraspinal Injections with Contaminated Steroid\n\n\n  Products. Please find detailed guidance at: <a href=\"http:\/\/emergency.cdc.gov\/HAN\/han00330.asp\">http:\/\/emergency.cdc.gov\/HAN\/han00330.asp<\/a>.\n\n\n  <\/li>\n\n\n<\/ol>\n\n\n<p>\n\n\n  It is important to note that <strong>no facilities in Delaware received the contaminated lots of methylprednisolone acetate (PF) 80mg\/ml\n\n\n  (the steroid injection)<\/strong>. Facilities in Delaware did receive other products from the New England Compounding Center (NECC) that\n\n\n  are included in the FDA expanded recall.\n\n\n<\/p>\n\n\n<h3>\n\n\n  Background\n\n\n<\/h3>\n\n\n<p>\n\n\n  On October 4, 2012, FDA advised medical professionals that all products produced by NECC should be retained, secured, and withheld from\n\n\n  use. On October 6, NECC announced a voluntary recall of all its products currently in circulation that were compounded at and distributed\n\n\n  from its Framingham, Massachusetts facility. On October 15, 2012, FDA further advised healthcare providers to follow-up with patients who\n\n\n  were administered any NECC injectable product <strong>on or after May 21, 2012<\/strong>, including an ophthalmic drug that is injectable\n\n\n  or used in conjunction with eye surgery, or a cardioplegic solution purchased from or produced by NECC.\n\n\n<\/p>\n\n\n<ol>\n\n\n  <li>\n\n\n    <strong>FDA provides NECC Customer List<br><\/strong> FDA made publicly available two lists of facilities that received products that\n\n\n    were shipped on or after May 21, 2012 from NECC\u2019s Framingham, MA facility. The lists were prepared based on information provided\n\n\n    by NECC, and FDA cannot vouch for the completeness or accuracy of the lists. Products shipped by NECC may be missing from the list and\n\n\n    facility information may be incomplete. Nevertheless, this is the best information that FDA has available to help inform facilities and\n\n\n    healthcare providers.<br>\n\n\n    <br>\n\n\n    The following is a list of Delaware facilities, publicly released by FDA, that received any NECC products shipped on or after May 21,\n\n\n    2012. The NECC customer lists can be accessed at: <a href=\"\/wp-content\/uploads\/sites\/10\/dph\/pdf\/UCM325467.pdf\">http:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/FungalMeningitis\/UCM325467.pdf<\/a>\n\n\n    and <a href=\"\/wp-content\/uploads\/sites\/10\/dph\/pdf\/UCM325466.pdf\">http:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/FungalMeningitis\/UCM325466.pdf<\/a>.<br>\n\n\n    <br>\n\n\n    Advanced Eye Care PA<br>\n\n\n    Anesthesia Providers<br>\n\n\n    Bayhealth Medical Center<br>\n\n\n    Beebe Medical Center<br>\n\n\n    Richard Bonder, MD, PA<br>\n\n\n    Christiana Health System<br>\n\n\n    Christiana Spine ASC<br>\n\n\n    Glasgow Medical Center<br>\n\n\n    Lewes Surgery Center<br>\n\n\n    Pain Center of Delaware<br>\n\n\n    St. Francis Hospital\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>CDC Issues Guidance on Management of Asymptomatic Patients Who Received Epidural or Paraspinal Injections with Contaminated\n\n\n    Steroid Products.<br><\/strong> The information in the CDC health alert below is specific to patients who received epidural and\n\n\n    paraspinal injections with the contaminated recalled lots of methylprednisolone acetate and who are asymptomatic (i.e. showing no signs\n\n\n    or symptoms of disease).<br>\n\n\n    <br>\n\n\n    CDC analysis suggests that the period of greatest risk for development of fungal meningitis among patients who received epidural or\n\n\n    paraspinal injections with contaminated products (referring to the 3 contaminated recalled lots of methylprednisolone acetate) is\n\n\n    during the first 6 weeks (42 days) after injection; therefore, additional monitoring of these patients should be considered.\n\n\n    Accordingly, CDC provides guidance for asymptomatic patients who received epidural or paraspinal injections with contaminated steroid\n\n\n    product within the last 6 weeks (42 days), and those who received such products longer than 6 weeks (42 days) ago. For specific details\n\n\n    about the updated guidance, see <a href=\"http:\/\/www.cdc.gov\/hai\/outbreaks\/clinicians\/guidance_asymptomatic_persons.html\">Guidance on\n\n\n    Management of Asymptomatic Patients Who Received Epidural or Paraspinal Injections with Contaminated Steroid Products<\/a> (<a href=\"http:\/\/www.cdc.gov\/hai\/outbreaks\/clinicians\/guidance_asymptomatic_persons.html\">http:\/\/www.cdc.gov\/hai\/outbreaks\/clinicians\/guidance_asymptomatic_persons.html<\/a>).<br>\n\n\n    <br>\n\n\n    CDC does <strong>not<\/strong> recommend initiation of antifungal treatment in the absence of diagnostic test results indicating fungal\n\n\n    meningitis in exposed patients who are asymptomatic. Currently available data do not suggest an added benefit to this approach in\n\n\n    comparison to the strategies outlined in the updated guidance, and patients may experience serious adverse drug events associated with\n\n\n    treatment.\n\n\n  <\/li>\n\n\n<\/ol>\n\n\n<h3>\n\n\n  Recommendations\n\n\n<\/h3>\n\n\n<ol>\n\n\n  <li>FDA is reiterating and updating its previous recommendation that follow-up with patients be done when the following three conditions\n\n\n  are met:<br>\n\n\n    -The medication was an injectable product purchased from or produced by NECC<strong>,<\/strong> including an ophthalmic drug that is\n\n\n    injectable or used in conjunction with eye surgery, or a cardioplegic solution,<br>\n\n\n    -The medication was <strong>shipped by NECC on or after May 21, 2012<\/strong>, and<br>\n\n\n    -The medication was administered to patients on or after May 21, 2012.<br>\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>Advice to NECC Customers<\/strong><br>\n\n\n    Customers identified on these lists should check their stocks to identify whether they have any products from the New England\n\n\n    Compounding Center (NECC), and they should immediately isolate any identified product from their drug supplies. All NECC products are\n\n\n    subject to voluntary recall. Customers with product on hand should contact NECC at 1-800-994-6322 or via fax at 508-820-1616 to obtain\n\n\n    instructions on how to return products to NECC.<br>\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>Advice to Patients<\/strong><br>\n\n\n    Patients who believe they received an injection or other product that was shipped <strong>by NECC on or after May 21, 2012<\/strong>\n\n\n    should remain vigilant for the signs and symptoms of infection, and contact their health care provider if they are concerned. The\n\n\n    meningitis outbreak has occurred in patients who received injections near the spine (back or neck). The signs and symptoms of\n\n\n    meningitis include fever, headache, stiff neck, nausea and vomiting, photophobia (sensitivity to light) and altered mental status.\n\n\n    Symptoms for infections following other types of injections at other body sites may vary, and are not limited to meningitis. Other\n\n\n    possible infections at other parts of the body (e.g., peripheral joints) may include fever; swelling, increasing pain, redness, warmth\n\n\n    at an injection site; visual changes, pain, redness or discharge from the eye; chest pain, or drainage from the surgical site\n\n\n    (infection within the chest).Patients should contact their healthcare provider if they have any of these signs or symptoms.<br>\n\n\n    <br>\n\n\n    Patients who received an NECC product prior to May 21, 2012 and who have not experiencing symptoms of infection to date are at less\n\n\n    risk of infection because of the amount of time that has elapsed since that date. FDA is not recommending these patients follow-up with\n\n\n    their healthcare providers unless they are experiencing symptoms of infection.<br>\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <strong>Advice to Healthcare Professionals<\/strong><br>\n\n\n    FDA advises healthcare professionals to follow-up with patients who have been administered an injectable product <strong>shipped by\n\n\n    NECC on or after May 21, 2012<\/strong>, including an ophthalmic drug that is injectable or used in conjunction with eye surgery, or a\n\n\n    cardioplegic solution. FDA does not urge patient follow-up at this time for NECC products of lower risk such as topicals (for example,\n\n\n    lotions, creams, eyedrops not used in conjunction with surgery) and suppositories, or for patients who may have received an NECC\n\n\n    product in these categories before May 21, 2012. Patients who received an NECC product prior to May 21, 2012 and who have not\n\n\n    experienced symptoms of infection to date are at less risk of infection because of the amount of time that has elapsed since that date.\n\n\n    FDA is not recommending that healthcare providers follow-up with these patients unless they have reported symptoms of infection.<br>\n\n\n    <br>\n\n\n    Health care professionals should retain and secure all remaining products purchased from NECC. All NECC products are subject to\n\n\n    voluntary recall. Clinics or customers with product on hand should contact NECC at 1-800-994-6322 or via fax at 508-820-1616 to obtain\n\n\n    instructions on how to return products to NECC.<br>\n\n\n    <br>\n\n\n    Clinicians and patients are also requested to report any suspected adverse events following use of these products to FDA\u2019s\n\n\n    MedWatch program at <strong>1-800-332-1088<\/strong> or <a href=\"http:\/\/www.fda.gov\/medwatch\">www.fda.gov\/medwatch<\/a>.\n\n\n  <\/li>\n\n\n<\/ol>\n\n\n<h4>\n\n\n  Additional Information\n\n\n<\/h4>\n\n\n<ul>\n\n\n  <li>\n\n\n    <a href=\"http:\/\/www.cdc.gov\/hai\/outbreaks\/meningitis.html\">Multistate Fungal Meningitis Outbreak Investigation<\/a> (<a href=\"http:\/\/www.cdc.gov\/hai\/outbreaks\/meningitis.html\">http:\/\/www.cdc.gov\/hai\/outbreaks\/meningitis.html<\/a>)\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <a href=\"http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm61e1012a1.htm?s_cid=mm61e1012a1_w\">MMWR Early Release: Multistate Outbreak of\n\n\n    Fungal Infection Associated with Injection of Methylprednisolone Acetate Solution from a Single Compounding Pharmacy \u2014 United\n\n\n    States, 2012.<\/a> <span style=\"text-decoration: underline\">(<\/span> <a href=\"http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm61e1012a1.htm?s_cid=mm61e1012a1_w\">http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm61e1012a1.htm?s_cid=mm61e1012a1_w<\/a>\n\n\n    <span style=\"text-decoration: underline\">)<\/span>\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <a href=\"http:\/\/www.bt.cdc.gov\/HAN\/han00328.asp\">CDC HAN Advisory: Update: Multistate Outbreak of Meningitis and Stroke Associated with\n\n\n    Potentially Contaminated Steroid Medication<\/a> (<a href=\"http:\/\/www.bt.cdc.gov\/HAN\/han00328.asp\">http:\/\/www.bt.cdc.gov\/HAN\/han00328.asp<\/a>)\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <a href=\"http:\/\/www.cdc.gov\/fungal\/\">CDC Website on Fungal Diseases<\/a> (<a href=\"http:\/\/www.cdc.gov\/fungal\/\">http:\/\/www.cdc.gov\/fungal\/<\/a>)\n\n\n  <\/li>\n\n\n  <li>\n\n\n    <a href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm322734.htm\">FDA Statement on Fungal Meningitis Outbreak<\/a> (<a href=\"http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm322734.htm\">http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm322734.htm<\/a>)\n\n\n  <\/li>\n\n\n  <li>Delaware Division of Public Health, Bureau of Epidemiology (24\/7): 1-888-295-5156\n\n\n  <\/li>\n\n\n  <li>Delaware Division of Public Health Webpage on meningitis: <a href=\"\/wp-content\/uploads\/sites\/10\/dph\/pdf\/meningocfaq.pdf\">http:\/\/dhss.delaware.gov\/dph\/files\/meningocfaq.pdf<\/a>\n\n\n  <\/li>\n\n\n<\/ul>\n\n\n<p>\n\n\n  ***************\n\n\n<\/p>\n\n\n<p>\n\n\n  You are receiving this message because you are a registered member of the Delaware Health Alert Network. If you are not a member and\n\n\n  would like to subscribe, please register at <a href=\"https:\/\/healthalertde.org\">https:\/\/healthalertde.org<\/a>\n\n\n<\/p><!--[END]-->\n\n  \n\n        <div class=\"panel panel-danger\">\n\n          <div class=\"panel-heading\">    \n\n      <h2>Categories of Health Alert messages:<\/h2>\n\n       <\/div>\n\n       <div class=\"panel-body\">\n\n      <ul>\n\n        <li><strong>Health Alert:<\/strong> Conveys the highest level of importance; warrants immediate action or attention.<\/li>\n\n        <li><strong>Health Advisory:<\/strong> Provides important information for a specific incident or situation; may not require immediate action.<\/li>\n\n        <li><strong>Health Update:<\/strong> Provides updated information regarding an incident or situation; unlikely to require immediate action.<\/li>\n\n            <\/ul>\n\n         <div><strong>NOTE: This page is for informational purposes only and dated material (e.g. temporary websites) may not be available.<\/strong><\/div>\n\n          <\/div> \n\n        <\/div><br>  \n\n\n\n      <\/div>\n\n    <\/div>\n\n  <\/div><!-- \/container -->\n\n  <\/div>","protected":false},"excerpt":{"rendered":"<p>Listen Delaware Health Alert Network #283 November 5, 2012 8:31 am Public Health Menu Home About About DPH Sections &#038; Programs Office Locations Contact Info Calendar Services A-Z Services Air &#038; Water Quality Birth, Death, &#038; Marriage Records Clinics Health Data &#038; Statistics Emergency Preparedness Health &#038; Wellness Healthy Homes Healthy Workplaces Laboratory Restaurant Inspections [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":9294,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-10252","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/10252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/comments?post=10252"}],"version-history":[{"count":1,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/10252\/revisions"}],"predecessor-version":[{"id":11428,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/10252\/revisions\/11428"}],"up":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9294"}],"wp:attachment":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/media?parent=10252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}