{"id":9335,"date":"2025-03-01T13:55:17","date_gmt":"2025-03-01T18:55:17","guid":{"rendered":"https:\/\/dhss.delaware.gov\/dph\/dphnsp4\/"},"modified":"2025-03-02T00:18:50","modified_gmt":"2025-03-02T05:18:50","slug":"dphnsp4","status":"publish","type":"page","link":"https:\/\/dhss.delaware.gov\/dph\/chca\/dphnsp4\/","title":{"rendered":"chca\/dphnsp4 ~  NSP Information for Professionals  &#8211; Delaware Health and Social Services &#8211; State of Delaware"},"content":{"rendered":"<div data-swiftype-index=\"true\">\n\n\n\n\n\n  <br>\n\n\n  \n\n\n  <div class=\"container\" id=\"main_header\">\n\n\n    <!-- BEGIN readspeaker div -->\n\n\n    <div class=\"rs_skip rsbtn rs_preserve\" id=\"readspeaker_button1\">\n\n\n      <a accesskey=\"L\" class=\"rsbtn_play\" href=\"https:\/\/app-na.readspeaker.com\/cgi-bin\/rsent?customerid=7262&#038;lang=en_us&#038;readid=main_content&#038;url=https:\/\/dhss.delaware.gov\/dph\/chca\/dphnsp4.html\" title=\"Listen to this page using ReadSpeaker\">\n\n\n        <span class=\"rsbtn_left rsimg rspart\"><span class=\"rsbtn_text\"><span>Listen<\/span><\/span><\/span>\n\n\n        <span class=\"rsbtn_right rsimg rsplay rspart\"><\/span>\n\n\n      <\/a>\n\n\n    <\/div>\n\n\n    <!-- END readspeaker div -->\n\n\n\n\n\n    \n\n\n    <header class=\"pull-left\">\n\n\n      <h1><!--[type=EDIT name=\"Page Title\"]-->Information for Health Professionals<!--[END]--><\/h1>\n\n\n    <\/header>\n\n\n  <\/div><br>\n\n\n \n\n\n  <div class=\"container\">\n\n\n    <div class=\"row\">\n\n\n      <div class=\"col-md-3\" id=\"leftCol\">\n\n\n        <div class=\"panel-group\" id=\"accordion\">\n\n\n          <div class=\"panel sectionmenu_panel\">\n\n\n            <div class=\"panel-heading\">\n\n\n              <p class=\"panel-title\"><a class=\"agency_nav\" data-parent=\"#accordion\" data-toggle=\"collapse\" href=\"#collapseOne\"><strong><i class=\"fa fa-align-justify fa-fw\"><\/i> Public Health Menu<\/strong><\/a><\/p>\n\n\n            <\/div>\n\n\n\n\n\n            <div class=\"panel-collapse collapse in\" id=\"collapseOne\">\n\n\n              <div class=\"panel-body\" id=\"clf_nav\">\n\n\n                  <ul class=\"nav nav-stacked nav-pills-clf\" id=\"agency_sidebar\">\n    <li><a href=\"\/dph\/\"><h2>Home <i class=\"fa fa-home fa-fw\"><\/i><\/h2><\/a><\/li>\n    <li class=\"toplevel\"><a data-parent=\"#agency_sidebar\" data-toggle=\"collapse\" href=\"#HomeMenu\"><h2>About <i class=\"fa fa-caret-right fa-fw\"><\/i><\/h2><\/a>\n      <ul class=\"panel-collapse collapse\" id=\"HomeMenu\">\n        <li><a href=\"\/dph\/about.html\">About DPH<\/a><\/li>\n        <li><a href=\"\/dph\/sections.html\">Sections &#038; Programs<\/a><\/li>\n        <li><a href=\"\/dph\/ofclocations.html\">Office Locations<\/a><\/li>\n        <li><a href=\"\/dph\/contact.html\">Contact Info<\/a><\/li>\n      \n        <li><a href=\"\/calendars.html\" target=\"_blank\">Calendar<\/a><\/li>\n      <\/ul>\n    <\/li>\n    <li 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href=\"\/dph\/lab\/labs.html\">Laboratory<\/a><\/li>\n        <li><a href=\"\/dph\/hsp\/feir.html\">Restaurant Inspections<\/a><\/li>\n        <li><a href=\"\/dph\/screen.html\">Screening and Testing<\/a><\/li>\n        <li><a href=\"\/dph\/chca\/dphwichominf01.html\">WIC<\/a><\/li>\n        <li><a href=\"\/dph\/servicesadd.html\">Additional Services<\/a><\/li><li>\n      <\/li><\/ul>\n    <\/li>\n    <li class=\"toplevel\"><a data-parent=\"#sidebar\" data-toggle=\"collapse\" href=\"#InformationMenu\"><h2>Information <i class=\"fa fa-caret-right fa-fw\"><\/i><\/h2><\/a>\n        <ul class=\"panel-collapse collapse\" id=\"InformationMenu\">\n        <li><a href=\"\/dph\/factsheetsaz.html\">A-Z Fact Sheets<\/a><\/li>\n        <li><a href=\"\/dph\/pubreportsaz.html\">A-Z Publications &#038; Reports<\/a><\/li>\n        <li><a href=\"\/dph\/diseasesandconditions.html\">Diseases &#038; Conditions<\/a><\/li>\n        <li><a href=\"\/dph\/faq.html\">FAQ&#8217;s<\/a><\/li>\n        <li><a href=\"\/dph\/php\/alerts.html\">Health Alerts<\/a><\/li>\n        <li><a href=\"\/dph\/healthylifestyles.html\">Healthy Lifestyles<\/a><\/li>\n        <li><a href=\"\/dph\/hipaa.html\">HIPAA<\/a><\/li>\n        <li><a href=\"\/dph\/regs.html\">Regulations<\/a><\/li>\n        <li><a href=\"\/dph\/forms.html\">Request Forms<\/a><\/li>\n        <li><a href=\"\/dph\/links.html\">Links &#038; Resources<\/a><\/li>\n        <li><a href=\"http:\/\/delaware.gov\/help\/foia_request.shtml\">FOIA Request Form<\/a><\/li>\n      <\/ul>\n    <\/li>\n    <li><a id=\"SocialMenuHeader\"><h2>Connect <i class=\"fa fa-thumbs-o-up fa-fw\"><\/i><\/h2><\/a>\n      <ul id=\"SocialMenu\">\n        <li class=\"facebook\"><a href=\"https:\/\/www.facebook.com\/DEPublicHealth\" target=\"_blank\" title=\"Division of Public Health Facebook Page\"><i class=\"fa fa-facebook-square fa-lg\"><\/i> Facebook<\/a><\/li>\n        <li class=\"twitter\"><a href=\"https:\/\/twitter.com\/Delaware_DHSS\" target=\"_blank\" title=\"Delaware Health and Social Services Twitter Account\"><i class=\"fa fa-twitter-square fa-lg\"><\/i> Twitter<\/a><\/li>\n        <!-- <li class=\"googleplus\"><a href=\"#\"><i class=\"fa fa-google-plus-square fa-lg\"><\/i> Google +<\/a><\/li>\n        <li class=\"flickr\"><a href=\"#\"><i class=\"fa fa-flickr fa-lg\"><\/i> Flickr<\/a><\/li>\n        <li class=\"youtube\"><a href=\"#\"><i class=\"fa fa-youtube-square fa-lg\"><\/i> Youtube<\/a><\/li>\n        <li class=\"instagram\"><a href=\"#\"><i class=\"fa fa-instagram fa-lg\"><\/i> Instagram<\/a><\/li>\n        <li class=\"linkedin\"><a href=\"#\"><i class=\"fa fa-linkedin-square fa-lg\"><\/i> Linkedin<\/a><\/li>\n        <li class=\"pinterest\"><a href=\"#\"><i class=\"fa fa-pinterest-square fa-lg\"><\/i> Pinterest<\/a><\/li> -->\n      <\/ul>\n    <\/li>\n  <\/ul>\n\n\n              <\/div>\n\n\n            <\/div>\n\n\n          <\/div>\n\n\n        <\/div><br>\n\n\n      <\/div>\n\n\n\n\n\n      <div class=\"col-md-9\" id=\"main_content\"> \n\n\n  <!--[type=HTMLEDIT name=\"Content\"]-->\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n<table class=\"table table-condensed table-border table-hover\">\n\n\n\n\n  <caption>\n\n\n\n\n    Summary of Disorders Screened for by the Delaware Newborn Screening Program\n\n\n\n\n  <\/caption>\n\n\n\n\n  <tbody>\n\n\n\n\n    <tr>\n\n\n\n\n      <th scope=\"col\">\n\n\n\n\n        Disorder\n\n\n\n\n      <\/th>\n\n\n\n\n      <th scope=\"col\">\n\n\n\n\n        Analyte Measured\n\n\n\n\n      <\/th>\n\n\n\n\n      <th scope=\"col\">\n\n\n\n\n        Results If Untreated\n\n\n\n\n      <\/th>\n\n\n\n\n      <th scope=\"col\">\n\n\n\n\n        Treatment\n\n\n\n\n      <\/th>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Phenylketonuria (PKU)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Phenylalanine level (Phe)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Mental retardation, seizures\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Low phe diet\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Congenital Hypothyroidism (CH)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Thyroid stimulating hormone (TSH)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Mental retardation, growth delay\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Thyroid hormone\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Galactosemia\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Total galactose, galactosemia enzyme (GALT)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Infection, cataracts, liver disease, mental retardation\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Galactose free diet\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Congenital Adrenal Hyperplasia (CAH)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        17-alpha hydroxy progesterone (17-OHP)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Electrolyte imbalance, shock, infant death\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Adrenal hormone replacement\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Hemoglobinopathies (most important -Sickle Cell Disease)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Hemoglobin isoelectric focusing\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Multiple medical conditions\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Antibiotic prohylaxis, specialized preventive health care\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Medium Chain Acyl-CoA Dehyrogenase (MCAD) Deficiency\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Levels of fatty acid acylcarnitines &#8211; C8, C6, C10:1\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Variable, but may include sudden death, seizures, neurologic syndromes\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Diet, avoidingfasts, certain medications\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Other Fatty Acid Oxidation (FAO) disorders\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Levels and ratios of various fatty acid acylcarnitines\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Variable, but may include sudden death, seizures, neurolgic syndromes\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Diet, avoiding fasts, certain medications\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Maple Syrup Urine Disease (MSUD)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Blood levels of leucine\/isoleucine\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Neonatal coma, seizures, acidosis, mental retardation\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Diet low in branched chain amino acids\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Glutaric Acidemia\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Acylcarnitine, C5-DC\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Seizures, athetosis, motor disability\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Diet, certain medications\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Other Organic Acid disorders\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Specific acylcarnitines\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Variable\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Variable\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Homocystinuria\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Methionine level\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Characteristic body habitus, eye anomalies, mental retardation, hypercoagulable\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Diet, medications\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Other disorders of amino acid metabolism\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Blood arginine, tyrosine, citrulline\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Variable\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Diet, variable\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>\n\n\n\n\n        Biotinidase Deficiency\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Biotinidase activity\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        Seizures, rash, mental retardation, hearing loss\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n        High dose biotin\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n        \n\n\n\n\n    \n\n\n\n\n    <tr>\n\n\n\n\n      <td>Severe Combined Immunodeficiency (SCID)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       T-cell Receptor Excision circles (TRECs)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Death\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Bone marrow\/stem cell transplantation\n\n\n\n\n      <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n      <td>MPS-I Mucopolysaccharidosis Type I\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Alpha-L-iduronidase (IDUA)      \n\n\n\n\n     <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Progressive debilitating neurological, gastrointestinal and musculoskeletal symptoms     \n\n\n\n\n     <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Bone marrow transplant\/enzyme replacement therapy\n\n\n\n\n     <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n        \n\n\n\n\n    \n\n\n\n\n    <tr>\n\n\n\n\n      <td>Glycogen Storage Disease Type II (Pompe)\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Alpha-glucosidase\n\n\n\n\n     <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Progressive muscle weakness and respiratory insufficiency     \n\n\n\n\n     <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Enzyme replacement therapy      \n\n\n\n\n    <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n        \n\n\n\n\n    \n\n\n\n\n    <tr>\n\n\n\n\n      <td>X-linked Adrenoleukodystrophy\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Lysophosphatidylcholine\n\n\n\n\n     <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Adrenal insufficiency and\/or neurological problems     \n\n\n\n\n     <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Hormone replacement and\/or stem cell transplantation   \n\n\n\n\n     <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n        \n\n\n\n\n    \n\n\n\n\n    <tr>\n\n\n\n\n      <td>Spinal Muscular Atrophy\n\n\n\n\n      <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Mutation in Spinal Motor Neuron 1 gene\n\n\n\n\n     <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Progressive muscle weakness, death     \n\n\n\n\n     <\/td>\n\n\n\n\n      <td>\n\n\n\n\n       Intrathecal protein infusions\/gene therapy\n\n\n\n\n     <\/td>\n\n\n\n\n    <\/tr>\n\n\n\n\n    <tr>\n\n\n\n\n\n\n\n\n\n<\/tr><\/tbody><\/table>\n\n\n\n\n<ul>\n\n\n\n\n  <li>\n\n\n\n\n    <a href=\"https:\/\/www.acmg.net\/ACMG\/Medical-Genetics-Practice-Resources\/ACT_Sheets_and_Algorithms.aspx\">American College of Medical Genetics (ACMG) ACT Sheets<\/a>\n\n\n\n\n  <\/li>\n\n\n\n\n  <li>\n\n\n\n\n    <a href=\"dphnsp1.html\">Return to the Newborn Screening Home Page<\/a>\n\n\n\n\n  <\/li>\n\n\n\n\n<\/ul>  <!--[END]-->\n\n\n  \n\n\n      <\/div>\n\n\n    <\/div>\n\n\n  <\/div><!-- \/container -->\n\n\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Listen Information for Health Professionals Public Health Menu Home About About DPH Sections &#038; Programs Office Locations Contact Info Calendar Services A-Z Services Air &#038; Water Quality Birth, Death, &#038; Marriage Records Clinics Health Data &#038; Statistics Emergency Preparedness Health &#038; Wellness Healthy Homes Healthy Workplaces Laboratory Restaurant Inspections Screening and Testing WIC Additional Services [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":9296,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-9335","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/comments?post=9335"}],"version-history":[{"count":1,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9335\/revisions"}],"predecessor-version":[{"id":10583,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9335\/revisions\/10583"}],"up":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9296"}],"wp:attachment":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/media?parent=9335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}