{"id":9616,"date":"2025-03-01T13:59:10","date_gmt":"2025-03-01T18:59:10","guid":{"rendered":"https:\/\/dhss.delaware.gov\/dph\/cjd\/"},"modified":"2025-03-02T00:28:48","modified_gmt":"2025-03-02T05:28:48","slug":"cjd","status":"publish","type":"page","link":"https:\/\/dhss.delaware.gov\/dph\/epi\/cjd\/","title":{"rendered":"epi\/cjd ~  Creutzfeldt-Jakob disease (CJD)   &#8211; Delaware Health and Social Services &#8211; State of Delaware"},"content":{"rendered":"<div data-swiftype-index=\"true\">\n\n\n\n\n\n  <br>\n\n\n  \n\n\n  <div class=\"container\" id=\"main_header\">\n\n\n    <!-- BEGIN readspeaker div -->\n\n\n    <div class=\"rs_skip rsbtn rs_preserve\" id=\"readspeaker_button1\">\n\n\n      <a accesskey=\"L\" class=\"rsbtn_play\" href=\"https:\/\/app-na.readspeaker.com\/cgi-bin\/rsent?customerid=7262&#038;lang=en_us&#038;readid=main_content&#038;url=https:\/\/dhss.delaware.gov\/dph\/epi\/cjd.html\" title=\"Listen to this page using ReadSpeaker\">\n\n\n        <span class=\"rsbtn_left rsimg rspart\"><span class=\"rsbtn_text\"><span>Listen<\/span><\/span><\/span>\n\n\n        <span class=\"rsbtn_right rsimg rsplay rspart\"><\/span>\n\n\n      <\/a>\n\n\n    <\/div>\n\n\n    <!-- END readspeaker div -->\n\n\n\n\n\n    \n\n\n    <header class=\"pull-left\">\n\n\n      <h1><!--[type=EDIT name=\"Page Title\"]-->Creutzfeldt-Jakob disease (CJD)<!--[END]--><\/h1>\n\n\n    <\/header>\n\n\n  <\/div><br>\n\n\n \n\n\n  <div class=\"container\">\n\n\n    <div class=\"row\">\n\n\n      <div class=\"col-md-3\" id=\"leftCol\">\n\n\n        <div class=\"panel-group\" id=\"accordion\">\n\n\n          <div class=\"panel sectionmenu_panel\">\n\n\n            <div class=\"panel-heading\">\n\n\n              <p class=\"panel-title\"><a class=\"agency_nav\" data-parent=\"#accordion\" data-toggle=\"collapse\" href=\"#collapseOne\"><strong><i class=\"fa fa-align-justify fa-fw\"><\/i> Public Health Menu<\/strong><\/a><\/p>\n\n\n            <\/div>\n\n\n\n\n\n            <div class=\"panel-collapse collapse in\" id=\"collapseOne\">\n\n\n              <div class=\"panel-body\" id=\"clf_nav\">\n\n\n                  <ul class=\"nav nav-stacked nav-pills-clf\" id=\"agency_sidebar\">\n    <li><a href=\"\/dph\/\"><h2>Home <i class=\"fa fa-home fa-fw\"><\/i><\/h2><\/a><\/li>\n    <li class=\"toplevel\"><a data-parent=\"#agency_sidebar\" data-toggle=\"collapse\" href=\"#HomeMenu\"><h2>About <i class=\"fa fa-caret-right fa-fw\"><\/i><\/h2><\/a>\n      <ul class=\"panel-collapse collapse\" id=\"HomeMenu\">\n        <li><a href=\"\/dph\/about.html\">About DPH<\/a><\/li>\n        <li><a href=\"\/dph\/sections.html\">Sections &#038; 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A prion is a nonliving, self-replicating infectious agent made of protein. It is thought to arise from a change in shape of a prion protein. This abnormally-folded protein is then thought to cause other prion proteins to change shape. This process leads to the destruction of brain cells.<\/p>\n\n\n\n\n\n\n\n<p>CJD is one of a family of related diseases found in many animal species, called Transmissible Spongiform Encephalopathies (TSEs). These include scrapie in sheep and Bovine Spongiform Encephalopathy (BSE) in cattle. BSE is also known as \u2018Mad Cow disease.\u2019<\/p>\n\n\n\n\n\n\n\n<p><strong><em>CJD is not related to Mad Cow disease.<\/em><\/strong><\/p>\n\n\n\n\n\n\n\n<p>\u00a0<\/p>\n\n\n\n\n\n\n\n<table class=\"table table-condensed table-hover\">\n\n\n\n <tbody>\n\n\n\n  <tr>\n\n\n\n   <td>\n\n\n\n   <p>CJD, the disease in humans, can take one of four forms including sporadic (sCJD), familial or inherited, acquired or iatrogenic and variant (vCJD).<\/p>\n\n\n\n\n\n\n\n   <ul>\n\n\n\n    <li><strong>Sporadic CJD (sCJD)<\/strong> is the most common of the human prion diseases and accounts for approximately 85% of all cases. The cause of sCJD is unknown. It occurs worldwide at a rate of approximately one case per 1 million population per year, although rates of up to two cases per million are not unusual. Most sporadic cases occur in people over 50 years of age and death usually occurs within months.<\/li>\n\n\n\n    <li><strong>Familial or Inherited CJD<\/strong> is the second most common form of CJD and accounts for approximately 10-15% of cases worldwide. People usually develop familial CJD at a younger age than sCJD and the course of illness is longer.<\/li>\n\n\n\n    <li><strong>Acquired or Iatrogenic CJD<\/strong> accounts for less than 1% of all cases. This form of CJD is caused by contamination with tissue from an infected person. While rare, human-to-human transmission of CJD can occur as the result of tissue implant, use of contaminated neurosurgical instruments, or administration of human hormones extracted from the organs of human cadavers. Today, no organs are procured from people known to be infected with CJD. Additionally, surgical instruments used on people with CJD undergo stringent chemical and autoclave sterilization methods or are never used again.<\/li>\n\n\n\n    <li><strong>Variant (vCJD)<\/strong> is another form of acquired CJD. This form was first reported in 1996 in the United Kingdom. It is thought to be transmitted through the consumption of beef from cattle infected with BSE or Mad Cow disease. There have been no known cases of vCJD that originated in the United States.<\/li>\n\n\n\n   <\/ul>\n\n\n\n   <\/td>\n\n\n\n   <td class=\"text-center\">\n\n\n\n   <h3>Basic<br>\n\n\n\n   CJD Information<\/h3>\n\n\n\n   <br>\n\n\n\n   <a href=\"\/wp-content\/uploads\/sites\/10\/dph\/pdf\/cjdmadcowfaq.pdf\">CJD FAQ Sheet<\/a><br>\n\n\n\n   <br>\n\n\n\n   [ <a href=\"\/wp-content\/uploads\/sites\/10\/dph\/txt\/cjdmadcowfaq.txt\">CJD FAQ Sheet &#8211;<br>\n\n\n\n   Text Version<\/a> ]<br>\n\n\n\n   __________<br>\n\n\n\n   <br>\n\n\n\n   <a href=\"https:\/\/www.cdc.gov\/prions\/cjd\/\">Centers for Disease Control<br>\n\n\n\n   and Prevention (CDC)<br>\n\n\n\n   About CJD<\/a><br>\n\n\n\n   __________<br>\n\n\n\n   <br>\n\n\n\n   <a href=\"https:\/\/www.cdc.gov\/prions\/index.html\">CDC &#8211; Prion Diseases<\/a><br>\n\n\n\n   __________<br>\n\n\n\n   \u00a0<\/td>\n\n\n\n  <\/tr>\n\n\n\n <\/tbody>\n\n\n\n<\/table>\n\n\n\n\n\n\n\n<p><span style=\"font-size:12px;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0<img decoding=\"async\" alt=\"CJD is confirmed only through brain biopsy or brain autopsy.\" class=\"img-thumbnail img-responsive\" src=\"\/wp-content\/uploads\/sites\/10\/dph\/img\/epi_cjd.gif\"><\/span><\/p>\n\n\n\n\n\n\n\n<h3>Family Support<\/h3>\n\n\n\n\n\n\n\n<p><a href=\"http:\/\/www.cjdfoundation.org\/\"><strong>CJD Foundation<\/strong><\/a><\/p>\n\n\n\n\n\n\n\n<p>Support is a key ingredient in coping with CJD. Support from those who have had similar experiences can be more helpful than any written information. The primary goal of the CJD Foundation is to provide support for CJD patients and their families.<\/p>\n\n\n\n\n\n\n\n<ul>\n\n\n\n <li>CJD Foundation Toll Free Helpline: 1-800-659-1991<\/li>\n\n\n\n<\/ul>\n\n\n\n\n\n\n\n<h3>CJD <a href=\"https:\/\/apps.who.int\/iris\/handle\/10665\/66707\">Infection Control Guidelines<\/a> &#8211; Information for the Healthcare Industry, Surgical Considerations &#038; Funeral Home \/ Crematory Practitioners<\/h3>\n\n\n\n\n\n\n\n<p>World Health Organization (WHO) Guidelines for Transmissible Spongiform Encephalopathies (TSE), March 1999<\/p>\n\n\n\n\n\n\n\n<ul>\n\n\n\n <li><strong><a href=\"https:\/\/www.cdc.gov\/prions\/cjd\/funeral-directors.html\">Additional information<\/a> on CJD for Funeral Home, Cemetary and Crematory Practitioners.<\/strong><\/li>\n\n\n\n <li><strong><a href=\"http:\/\/www.nfda.org\/\">National Funeral Directors Association<\/a><\/strong><\/li>\n\n\n\n<\/ul>\n\n\n\n\n\n\n\n<h3>National Prion Disease Pathology Surveillance Center (NPDPSC)<\/h3>\n\n\n\n\n\n\n\n<p>The <a href=\"http:\/\/www.cjdsurveillance.com\/\">NPDPSC<\/a> was established in 1997 at the Division of Neuropathology of Case Western Reserve University and is sponsored by the American Association of Neuropathologists (AANP). The NPDPSC monitors the occurrence of prion disease through characterization of brain tissue pathology from clinically diagnosed cases of CJD. <strong>A confirmatory diagnosis of CJD can only be made through brain biopsy or brain autopsy. Autopsy provides the only method to fully classify the type of CJD (sporadic, familial, iatrogenic, or variant).<\/strong> The NPDPSC can help establish the diagnosis of prion disease by analyzing cerebrospinal fluid (CSF), blood, and brain tissue obtained either at biopsy or autopsy.<\/p>\n\n\n\n\n\n\n\n<p>For questions regarding services offered by the NPDPSC or assistance in arranging an autopsy, please call the Center at (216-368-0587).<\/p>\n\n\n\n\n\n\n\n<h3><a href=\"http:\/\/www.delmarvablood.org\/\">Blood Bank of Delmarva (BBD)<\/a><\/h3>\n\n\n\n\n\n\n\n<p>Although there have been no documented cases of a patient developing CJD from a transfusion of blood or plasma, all potential donors are screened to determine if they fall into a CJD risk group that has been determined by the Food and Drug Administration (FDA).<\/p>\n\n\n\n\n\n\n\n<p>BBD defers all potential donors who may be at risk for CJD according to the following criteria:<\/p>\n\n\n\n\n\n\n\n<ol>\n\n\n\n <li>People who have received human pituitary-derived growth hormone.<\/li>\n\n\n\n <li>People who have received a dura mater transplant.<\/li>\n\n\n\n <li>People told their families are at risk for CJD.<\/li>\n\n\n\n <li>People with one or more blood relatives with CJD.<\/li>\n\n\n\n<\/ol>\n\n\n\n\n\n\n\n<p><strong>NOTE:<\/strong> A person who has only one family member with CJD may be at increased risk for developing the disease. However, he or she is much less likely to develop CJD than a person who has two or more family members diagnosed with CJD.<\/p>\n\n\n\n\n\n\n\n<p>For more information, contact Blood Bank of Delmarva Donor Advocate at (302)737-8405 (or 1-800-533-6957).<\/p>\n\n\n\n\n\n\n\n<h3>Reporting and Surveillance<\/h3>\n\n\n\n\n\n\n\n<p>CJD became a reportable condition in Delaware in 2006: <a href=\"https:\/\/regulations.delaware.gov\/AdminCode\/title16\/Department%20of%20Health%20and%20Social%20Services\/Division%20of%20Public%20Health\/Health%20Promotion%20and%20Disease%20Prevention\/4202.pdf\">Regulations for the Control of Communicable and Other Disease Conditions<\/a><\/p>\n\n\n\n\n\n\n\n<p>Purpose of Reporting and Surveillance:<\/p>\n\n\n\n\n\n\n\n<ul>\n\n\n\n <li>To monitor trends in the epidemiology of human prion diseases.<\/li>\n\n\n\n <li>To maximize laboratory confirmation of suspected cases in collaboration with the <a href=\"http:\/\/www.cjdsurveillance.com\/\">National Prion Disease Pathology Surveillance Center.<\/a><\/li>\n\n\n\n <li>To detect the emergence of vCJD or novel prion diseases in the United States.<\/li>\n\n\n\n <li>To prevent potential iatrogenic (acquired) transmission.<\/li>\n\n\n\n<\/ul>\n\n\n\n\n\n\n\n<p><strong>Healthcare providers should <a class=\"anchors_link\" href=\"\/dph\/contact.html#epi\">contact the Delaware Division of Public Health (DPH), Bureau of Epidemiology<\/a> to report any suspect case of CJD.<\/strong><\/p>\n\n\n\n\n\n\n\n<h3>Additional Resources:<\/h3>\n\n\n\n\n\n\n\n<ul>\n\n\n\n <li><a href=\"https:\/\/www.ninds.nih.gov\/health-information\/patient-caregiver-education\/fact-sheets\/creutzfeldt-jakob-disease-fact-sheet?search-term=CJD\">National Institute of Neurological Disorders and Stroke (NINDS)<\/a><\/li>\n\n\n\n <li><a href=\"http:\/\/www.rarediseases.org\/\">National Organization of Rare Disorders (NORD)<\/a><\/li>\n\n\n\n <li><a href=\"http:\/\/www.cjdsupport.net\/\">CJD Support Network, United Kingdom<\/a><\/li>\n\n\n\n <li><a href=\"http:\/\/www.cjd.ed.ac.uk\/\">The National Creutzfeldt &#8211; Jakob disease Surveillance Unit (NCJDSU)<\/a><\/li>\n\n\n\n<\/ul>\n\n\n\n\n\n\n\n<p>\u00a0<\/p>\n\n\n\n\n\n\n\n<p style=\"text-align:center\"><span style=\"color:#A52A2A;\"><strong>Office of Infectious Disease Epidemiology<\/strong><\/span><\/p>\n\n\n\n\n\n\n\n<p style=\"text-align:center\"><span style=\"color:#A52A2A;\"><strong>24\/7 Emergency Contact Number: 1-888-295-5156<\/strong><\/span><\/p>\n\n\n\n\n\n\n\n<p>\u00a0<\/p>\n\n\n\n\n\n\n\n<p class=\"text-center\"><a href=\"epi.html\">Return to Epidemiology Home Page<\/a><\/p>\n\n\n\n\n\n\n\n<p>\u00a0\n\n\n\n<\/p><p><br>\n\n\n\n<\/p><p class=\"smalltext\"><a href=\"http:\/\/www.adobe.com\/products\/acrobat\/readstep2.html\"><img loading=\"lazy\" decoding=\"async\" alt=\"Download Adobe Acrobat Reader\" height=\"21\" src=\"\/wp-content\/uploads\/dhss\/img\/getacro60.gif\" width=\"60\"><\/a> Please note: Some of the files available on this page are in Adobe PDF format which requires Adobe Acrobat Reader.  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If you are using an assistive technology unable to read Adobe PDF, please either view the corresponding text only version (if available) or visit Adobe&#8217;s <a href=\"http:\/\/access.adobe.com\">Accessibility Tools page<\/a>.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n<p>\u00a0<\/p>\n\n\n\n  <!--[END]-->\n\n\n  \n\n\n      <\/div>\n\n\n    <\/div>\n\n\n  <\/div><!-- \/container -->\n\n\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Listen Creutzfeldt-Jakob disease (CJD) Public Health Menu Home About About DPH Sections &#038; Programs Office Locations Contact Info Calendar Services A-Z Services Air &#038; Water Quality Birth, Death, &#038; Marriage Records Clinics Health Data &#038; Statistics Emergency Preparedness Health &#038; Wellness Healthy Homes Healthy Workplaces Laboratory Restaurant Inspections Screening and Testing WIC Additional Services Information [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":9615,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-9616","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/comments?post=9616"}],"version-history":[{"count":1,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9616\/revisions"}],"predecessor-version":[{"id":10830,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9616\/revisions\/10830"}],"up":[{"embeddable":true,"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/pages\/9615"}],"wp:attachment":[{"href":"https:\/\/dhss.delaware.gov\/dph\/wp-json\/wp\/v2\/media?parent=9616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}