DPH GUIDANCE ON TREATMENT OF SEXUALLY TRANSMITTED DISEASES DURING DOXYCYCLINE SHORTAGE
On January 18, 2013 the Food and Drug Administration (FDA) reported a shortage of Doxycycline. Doxycycline is a recommended and
frequently used therapy for common sexually transmitted diseases and associated syndromes. Doxycycline tablets/capsules are currently
available in very limited supplies.
CDC recommendations and alternative regimens are listed below and also outlined at: http://www.cdc.gov/std/treatment/doxycyclineShortage.htm.
Chlamydia and Nongonococcal urethritis
- Azithromycin 1 g orally in a single dose
- Ceftriaxone 250 mg IM in a single dose and Azithromycin 1 g orally in a single dose
Syphilis (In penicillin allergic non-pregnant patients only)
- Primary or secondary syphilis: Tetracycline 500 mg orally four times daily for 14 days
- Late latent syphilis: Tetracycline 500 mg orally four times daily for 28 days
- Ceftriaxone 250 mg IM in a single dose and Tetracycline 500 mg four times daily for 10 days
Pelvic Inflammatory Disease*
- Ceftriaxone 250 mg IM in a single dose and Clindamycin 450 mg orally four times daily for 14 days, with or without Metronidazole 500
mg orally twice a day for 14 days
*see STD Treatment Guidelines at http://www.cdc.gov/std/treatment/2010/default.htm for additional regimens.
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