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Delaware Health Alert Network #296

January 30, 2013 12:13 pm


Health Alert
DPH GUIDANCE ON TREATMENT OF SEXUALLY TRANSMITTED DISEASES DURING DOXYCYCLINE SHORTAGE


Background

On January 18, 2013 the Food and Drug Administration (FDA) reported a shortage of Doxycycline. Doxycycline is a recommended and frequently used therapy for common sexually transmitted diseases and associated syndromes. Doxycycline tablets/capsules are currently available in very limited supplies.

Recommendations

CDC recommendations and alternative regimens are listed below and also outlined at: http://www.cdc.gov/std/treatment/doxycyclineShortage.htm.

Chlamydia and Nongonococcal urethritis

  • Azithromycin 1 g orally in a single dose

Gonorrhea

  • Ceftriaxone 250 mg IM in a single dose and Azithromycin 1 g orally in a single dose

Syphilis (In penicillin allergic non-pregnant patients only)

  • Primary or secondary syphilis: Tetracycline 500 mg orally four times daily for 14 days
  • Late latent syphilis: Tetracycline 500 mg orally four times daily for 28 days

Epididymitis

  • Ceftriaxone 250 mg IM in a single dose and Tetracycline 500 mg four times daily for 10 days

Pelvic Inflammatory Disease*

  • Ceftriaxone 250 mg IM in a single dose and Clindamycin 450 mg orally four times daily for 14 days, with or without Metronidazole 500 mg orally twice a day for 14 days

*see STD Treatment Guidelines at http://www.cdc.gov/std/treatment/2010/default.htm for additional regimens.

Additional Information

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